Research in the Aran Lab

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Hi my name is Kiana Iran and I'm an associate professor by engineering here at the graduate institute in my lab. We develop next generation CRISPR based devices for a variety of applications. We also develop organ on a chip devices to understand the aging process as well as drug discovery applications for most of our projects. We collaborate with industrial partner as well as academic partners. Let's walk through the lab and learn more about some of our innovative projects. Hi I'm Jonah linda castro and I'm a PhD candidate within the Iran lab and work on aging research with our academic collaborators at U. C. Berkeley and UC SAN Francisco. One of the main focuses of our aging research is investigating the role that different blood components have on aging specifically Eritrea sites and blood based nanoparticles known as ex zones that may have previously unknown effects on brain health or may carry secret messages to and from cells between different age groups and people with different neurodegenerative diseases. Without relying on traditional micro phonetic technologies. We have recently developed an innovative blood green barrier organ on a chip device term micro electrical Phoebe B. In collaboration with our colleagues at U. C. Berkeley. We have used this system to understand the effects of a retro sites on blood brain barrier integrity. These findings are important because development of neurodegenerative diseases are increasing. However there are little solutions to early treatment which is when patients have better outcomes of ruth recites may have the potential to be therapeutic in some cases of poor brain health. We are now applying this technology to Alzheimer's and A L. S patient samples with our collaborators at UC Berkeley and UC SAn Francisco with the goals of discovering novel treatments for neurodegenerative diseases. Hi, my name is luke gillis and I'm electrical engineering student and research associate here at the Iran lab. I primarily work with the engineering team where we work towards optimizing the usability of our instruments in close collaboration with industry partners. I'm a PhD candidate in the lab and I'm working on a National Science Foundation. I work the project we aim to develop the next generation of graphene field effect transistors to detect single molecule interactions. So a nobel high speed non electronic platform advancements toward single molecule interactions are critical in order to further the understanding of enzyme kinetics specifically enzymes in the crisper cas complex family. I have a PhD degree in our ministry and working as a senior research scientist in doctor on our lab at the technological institute. I'm working on development of biosensors for sponsored research projects. Hi, my name is Antonio kappas L. A. And I'm a postgraduate research intern in the Iran lab and I work on our industrial sponsored research projects. This research focuses on developing next generation CRISPR based biosensors in this project. We worked with our industry collaborator cardio bio as well as with world renowned CRISPR experts at Vilnius University. The rapid detection of nucleic acids made possible by CRISPR based biosensors has a wide variety of clinical applications including the detection of various forms of cancer, the identification of genetic mutations and the recognition of viral genetic material. Hello, my name is Maria mora fianna, an apostate or a scholar in our own laboratory. The primary focus of our research is to develop novel micro political platform to perform liquid biopsies of extra psalms from different cell types. Extra psalms play a significant role in cellular communication and can play a critical role in disease diagnosis and treatment or micro politic device. We can control release of extras arms from healthy and unhealthy service while also measuring the rate of release in different cell types with an inter dissimilarity of chemists, biologists and engineers. We aim to leverage micro floating technology in order to identify new pathways of expose on biology. Hi, my name is Primary and I'm a PhD Canon here in the wrong lab. A common theme of our group is to miniaturize and improve upon existing technologies for this project. We are seeing developing novel program, a tool that can replace these larger gel based proteomics techniques and this new system they were developing will not only be smaller and faster but much more robust and sensitive. In my lab we imagine what can be done with modern science and technology and that is our driving force to developing innovative solution for societal needs.